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Gates, B. Responding to Covid�A once-in-a-century pandemic?. Gorbalenya, A. Article Google Scholar. Pallesen, J. Wrapp, D. Cryo-EM structure of the nCoV spike in the prefusion conformation. Science , � Lee, S. Recent advances of vaccine adjuvants for infectious diseases. Immune Netw. Shi, S. Vaccine adjuvants: Understanding the structure and mechanism of adjuvanticity. Tseng, C. Hotez, P. Campbell, J.

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Immunology 2 , � Download references. We thank Dr. Graham, Dr. Kizzmekia S. We are grateful for the participation of Dr. Michael D. Malison, Dr. Han van den Bosch, Dr. In addition, we would like to acknowledge Dr. Robert L. Coffman, John D. You can also search for this author in PubMed Google Scholar.

All authors reviewed and approved of the final version of the manuscript. Correspondence to Charles Chen. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material.

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Reprints and Permissions. Kuo, TY. Sci Rep 10, Download citation. Received : 13 August Accepted : 03 November Published : 18 November Advanced Drug Delivery Reviews Science Advances Viruses Prevention, Diagnosis, Treatment Vaccines By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

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Download PDF. Subjects Immunology Microbiology. Abstract The COVID pandemic is a worldwide health emergency which calls for an unprecedented race for vaccines and treatment.

Introduction COVID was first identified as a cause of severe pneumonia cases in December in association with a seafood market in Wuhan, China 1. Results Induction of potent neutralizing antibodies by CpG and aluminum hydroxide-adjuvanted S-2P To facilitate establishment of stable clones for clinical studies and commercial production, we applied the ExpiCHO system as the expression system of S-2P antigen.

Figure 1. Full size image. Figure 2. Figure 3. Figure 4. Figure 5. Figure 6. Figure 7. Figure 8. Discussion In this study, we showed that in mice, two injections of a subunit vaccine consisting of the prefusion spike protein S-2P adjuvanted with CpG and alum were effective in inducing potent neutralization activity against both pseudovirus expressing wild-type and DG variant spike proteins, and wild-type SARS-CoV References 1.

Article Google Scholar 8. Article Google Scholar Article PubMed Google Scholar Google Scholar Acknowledgements We thank Dr. View author publications. Ethics declarations Competing interests The authors declare no competing interests.

Additional information Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Supplementary information. Supplementary Information. About this article. Cite this article Kuo, TY. Steinbuck , Lochana M. Seenappa , Aniela Jakubowski , Lisa K.

McNeil , Christopher M. Mousa Viruses General characteristics of adjuvants and their mechanisms of action part 2 N. Alpatova , Zh. Avdeeva , S. Lysikova , O. Golovinskaya , L. Bondarev BIOpreparations. Hassain , Fatiha M. Benslimane , Asmaa A. From Wikipedia, the free encyclopedia. This is the latest accepted revision , reviewed on 1 April Co-founder of Google. In this Eastern Slavic name , the patronymic is Mikhaylovich and the family name is Brin.

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